Study of AMN107 With Imatinib in Gastrointestinal Stromal Tumors (GIST)

Exclusion Criteria

• •Patients with prior or concomitant malignancies other than GIST with the exception of previous or concomitant basal cell skin cancer or previous cervical carcinoma in situ.
• •A history of impaired cardiac function or uncontrolled cardiovascular disease.
• •Severe and/or uncontrolled concurrent disease that could cause unacceptable safety risks such as impairment of gastrointestinal (GI) function or GI disease that may significantly alter the absorption of AMN107.
• •Currently taking certain medications that could affect an electrocardiogram result.
• •Women who are pregnant or breast feeding.
• •Patients unwilling or unable to comply with the protocol.