Vorinostat in Treating Patients With Relapsed or Refractory Advanced Hodgkin's Lymphoma

Inclusion Criteria

• •Patients must have histologically or cytologically confirmed relapsed/refractory Hodgkin's lymphoma of any subtype; patients with lymphocyte predominant Hodgkin's disease (LPHD) are also eligible; clear evidence of disease progression or lack of response after the most recent therapy, including local radiation is required
• •Patients must be willing to submit specimens for correlative studies
• •All patients must have bidimensionally measurable disease documented within 28 days prior to registration; patients with non-measurable disease in addition to measurable disease must have all non-measurable disease assessed within 42 days prior to registration
• •Patients must have unilateral bone marrow aspirate and biopsy performed within 42 days prior to registration
• •Patients may have had up to five prior chemotherapy regimens
• •Patients must have completed chemotherapy at least 28 days prior to registration and all toxicities must have resolved (in the opinion of the treating investigator); if last regimen included nitrosoureas or mitomycin then 42 days must have elapsed since completion of treatment; patients must not have taken valproic acid, or another histone deacetylase inhibitor, for at least 14 days prior to registration
• •Patients must have completed all radiotherapy at least 14 days prior to registration and all toxicities must have resolved (in the opinion of the treating investigator)
• •Patients who relapse after autologous stem cell transplant may be enrolled if they are at least three months after transplant, and after allogeneic transplant if they are at least one year posttransplant; patients should have no active related infections (i.e., fungal or viral); in the case of allogeneic transplant relapse, there should be no active acute graft versus host disease (GvHD) of any grade, and no chronic graft versus host disease other than mild skin, oral, or ocular GvHD not requiring systemic immunosuppression
• •Patients must have a Zubrod performance status of 0-2
• •Patients must have a CT scan of the chest/abdomen and pelvis performed within 28 days prior to registration
• •Patients must not have clinical evidence of central nervous system involvement by lymphoma; any laboratory or radiographic tests performed to assess CNS involvement must be negative within 42 days of registration
• •Serum LDH must be measured within 28 days prior to registration
• •Absolute neutrophil count \>- 1,000/mcL
• •Platelet count \>= 100,000/mcL
• •SGOT/SGPT \< 2.5 x the institutional upper limit of normal
• •Serum creatinine \< 2 x the institutional upper limit of normal
• •Patients with a history of allergic reactions attributed to compounds of similar chemical or biological composition to SAHA are ineligible