Sorafenib Tosylate in Treating Patients With Progressive Metastatic Neuroendocrine Tumors

You may be eligible if

• Criteria:
• Histologically confirmed neuroendocrine tumor:
• * Carcinoid tumor OR islet cell carcinoma/other well-differentiated tumor
• * No anaplastic or high-grade histology
• * Metastatic disease
• Measurable disease
• No thyroid carcinoma of any histology, thymoma, or pheochromocytoma/paraganglioma
• No known brain metastases
• Performance status:
• * Eastern Cooperative Oncology Group (ECOG) 0-2
• Life expectancy:
• * At least 24 weeks
• Hematopoietic:
• * Absolute neutrophil count \>= 1,500/mm3
• * Platelet count \>= 100,000/mm3
• * No bleeding diathesis
• Hepatic:
• * Bilirubin =\< 2 times upper limit of normal (ULN)
• * Aspartate aminotransferase (AST) =\< 3 times ULN (5 times ULN if liver metastases are present)
• * International normalized ratio (INR) normal
• * PTT normal
• Renal:
• * Creatinine =\< 1.5 times ULN
• Cardiovascular:
• No poorly controlled hypertension; No symptoms of congestive heart failure; No unstable angina pectoris; No cardiac arrhythmia
• Gastrointestinal:
• * Able to swallow capsules intact
• * No gastrointestinal tract disease resulting in an inability to take oral medication (e.g., dysphagia)
• * No requirement for IV alimentation
• * No active peptic ulcer disease
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception
• No ongoing or active infection
• No psychiatric illness or social situation that would preclude study compliance
• No other invasive malignancy within the past 3 years except adequately treated basal cell or squamous cell skin cancer or carcinoma in situ of the cervix
• No other uncontrolled illness
• At least 4 weeks since prior interferon
• No more than 1 prior systemic chemotherapy regimen:
• Chemoembolization is not considered systemic chemotherapy
• At least 4 weeks since prior chemoembolization
• At least 3 weeks since prior radiotherapy
• No prior procedures adversely affecting intestinal absorption
• At least 4 weeks since prior hepatic artery embolization
• No other prior systemic therapy
• No other concurrent investigational treatment
• No concurrent combination antiretroviral therapy for HIV-positive patients
• No concurrent enzyme-inducing anticonvulsants (e.g., carbamazepine, phenobarbital, or phenytoin)
• No concurrent rifampin
• No concurrent Hypericum perforatum (St. John's wort)
• Prior or concurrent octreotide for symptomatic treatment allowed
• No concurrent therapeutic anticoagulation:
• Concurrent prophylactic anticoagulation (i.e., low dose warfarin) of venous or arterial access devices allowed provided requirements for INR or PTT are met
• At least 4 weeks since prior major surgery
• Recovered from all prior therapy