A Study to Evaluate PT-523 in Patients With Refractory Leukemia

You may not be if

• Only patients with refractory ALL or CML in lymphoid blastic phase are eligible for phase II.
• ECOG performance status 0 - 2.
• Adequate organ function and bone marrow reserve.
• At least 4 weeks must have elapsed from the time of major surgery.
• Use of appropriate contraceptive method.
• Signed patient informed consent.
• Known human immunodeficiency virus (HIV).
• Active heart disease including myocardial infarction within previous 3 months, symptomatic coronary artery disease, arrhythmias not controlled by medication, or uncontrolled congestive heart failure.
• Patients receiving any other standard or investigational treatment for their leukemia other than corticosteriods, hydroxyurea, and 6-mercaptopurine.
• Any medical condition which, in the opinion of the investigator, places the patient at an unacceptably high risk for toxicities.