Triptorelin for Ovary Protection in Childhood Onset Lupus

Exclusion Criteria

• •Male patients of any age
• •Female patients with a Tanner stage of 1
• •Positive blood pregnancy test at screening or taking oral or injectable birth-control medications
• •Prior exposure to more than one dose of gonadotoxic medications including cyclophosphamide
• •History of allergic or adverse response to triptorelin
• •Diagnosed with hypogonadism prior to cyclophosphamide exposure
• •Acutely life-threatening disease activity that prohibits inclusion in a clinical trial
• •History of clinically significant gastrointestinal tract, renal, hepatic, endocrine, oncologic, pulmonary (asthma accepted), or cardiovascular disease; or a history of tuberculosis, epilepsy, diabetes, depression, psychosis, or any other non-cSLE condition, which in the opinion of the physician, would jeopardize the safety of the subject or impact the validity of the study results
• •Patient age 18 years of younger with severe depression as defined by a CDI (Children's Depression Inventory) score of \> 23 or a patient age 19 to 21 years with severe depression as defined by a BDI (Beck's Depression Inventory) score \> 29
• •Patient admits to suicidal thoughts at screening visit
• •Bone mineral density lower than z = -2.0.