Vascular Effects of Rosiglitazone Versus Glyburide in Type 2 Diabetic Patients

Exclusion Criteria

• •Thiazolidinedione or sulfonylurea use in previous 30 days (may undergo washout period of 30 days)
• •Known contraindications to use of thiazolidinedione or sulfonylurea
• •Female patients must be postmenopausal, surgically sterile, or using adequate contraception
• •Uncontrolled hyperlipidemia according to American Heart Association (AHA) guidelines
• •Subcutaneous insulin use
• •Elevated liver enzymes (2.5 times the upper limit of the reference range)
• •Serum creatinine \>160 mmol/l
• •Anemia (Hb \<11 g/dl for men or \<10 g/dl for women)
• •Body mass index (BMI) \<22 or \>42 kg/m2
• •History of ketoacidosis
• •Angina/New York Health Academy class III/IV cardiac insufficiency
• •Electrocardiographic evidence of marked left ventricular hypertrophy
• •Uncontrolled hypertension according to AHA guidelines
• •Hemoglobinopathy