Study of Tenofovir Disoproxil Fumarate (TDF) for Prevention of HIV

You may be eligible if

• Be willing and able to give informed consent
• Be 18 years or older
• Be willing to use study product as directed
• Be willing to adhere to follow-up schedule
• Be willing to participate in the study for up to 12 months
• Be in general good health (no active, serious infections that require parenteral antibiotics, no active clinically significant medical conditions, including heart disease, diabetes, asthma, alcoholism, and cancer)
• Meet at least one of these three high risk criteria: \*Sex with sex worker/bar girl in last 3 months;
• * Sex with 2 or more women in last 3 months;
• * Sexually transmitted disease (STD) in last 3 months
• Have absence of HIV antibodies by rapid test (at screening and enrollment visit)
• Have absence of hepatitis B (HB) surface antigen (sAg)
• Have adequate renal function (serum creatinine \<1.5 mg/dL)
• Have adequate liver function (hepatic transaminases (ALT \<54 U/L and AST\<46 U/L)
• Have adequate serum phosphorus (\>2.2 mg/dL)
• Not be intending to relocate out of the area for the duration of the study participation and does not have a job or other obligations that may require long absences from the area
• Not be receiving an experimental HIV vaccine