Effect of Metformin Versus Repaglinide Treatment in Non-Obese Type 2 Diabetic Patients Uncontrolled by Diet

Inclusion Criteria

• •Type-2 diabetes, defined as:
• •Age at onset of diabetes ≥ 40 years
• •Fasting serum C-peptide ≥ 300 pmol/l or a non-fasting or glucagon-stimulated serum C-peptide ≥ 600 pmol/l
• •No history of ketonuria or ketoacidosis.
• •BMI ≤ 27 kg/m2.
• •Fasting plasma-glucose ≥ 6.5 mmol/l after at least one month of diet-only treatment.
• •HbA1c ≤ 9.5% at ongoing oral anti-hyperglycaemic agents. HbA1c ≥ 6.5% after minimum one month of diet-only treatment.
• •Weight-loss of no more than 5.0 kg during the last 6 months prior to enrolment.