S0408: Capecitabine, Oxaliplatin, and Bevacizumab in Pts Undergoing Surgery for Liver Mets From Colorectal Cancer

You may be eligible if

• DISEASE CHARACTERISTICS:
• Diagnosis of hepatic metastases secondary to colorectal cancer by percutaneous hepatic biopsy
• Resectable hepatic metastases by any of the following:
• * Minor resection (i.e., less than a hemihepatectomy)
• * Major resection (i.e., hemihepatectomy or extended hepatectomy)
• * Bilobar resection (including atypical resection)
• Synchronous primary tumor and hepatic metastases allowed
• Radiologic evidence of hepatic metastases by multiphasic contrast-enhanced spiral CT scan
• Resectable primary colorectal cancer that is in place allowed
• Measurable disease
• No evidence of extrahepatic metastases by chest x-ray or CT scan of the chest
• PATIENT CHARACTERISTICS:
• Age
• 18 and over
• Performance status
• Zubrod 0-1
• Life expectancy
• Not specified
• Hematopoietic
• Hemoglobin ≥ 9.0 g/dL
• WBC ≥ 3,000/mm\^3
• Platelet count ≥ 100,000/mm\^3
• Absolute neutrophil count ≥ 1,500/mm\^3
• Hepatic
• Bilirubin ≤ 2 times upper limit of normal (ULN)
• SGOT or SGPT ≤ 2.5 times ULN
• Renal
• Creatinine clearance ≥ 60 mL/min
• Urine protein/creatinine ratio \< 1 OR
• Urine protein \< 1 g by 24-hour urine collection
• Cardiovascular
• No uncontrolled hypertension (i.e., blood pressure \> 150/90 mm Hg)
• * History of hypertension allowed provided it is well controlled on a stable regimen of anti-hypertensive therapy
• No arterial thromboembolic event within the past 12 months, including any of the following:
• * Transient ischemic attack
• * Cerebrovascular accident
• * Unstable angina
• * Myocardial infarction
• No peripheral vascular disease ≥ grade 2
• Other
• Not pregnant or nursing
• Fertile patients must use effective contraception
• No pre-existing peripheral neuropathy ≥ grade 2
• No other malignancy within the past 5 years except adequately treated basal cell or squamous cell skin cancer or carcinoma in situ of the cervix
• PRIOR CONCURRENT THERAPY:
• Biologic therapy
• Not specified
• Chemotherapy
• More than 6 months since prior adjuvant chemotherapy for the primary tumor
• No prior systemic chemotherapy for metastatic disease
• No prior hepatic artery infusion chemotherapy for metastatic disease
• Endocrine therapy
• Not specified
• Radiotherapy
• No prior radiotherapy for metastatic disease
• Surgery
• More than 7 days since prior colonoscopy or fine needle aspiration
• More than 28 days since prior major invasive surgery or open biopsy
• Other
• At least 4 weeks since prior and no concurrent sorivudine or brivudine
• No prior radiofrequency ablation for metastatic disease
• No prior cryotherapy for metastatic disease
• No other prior ablative techniques for metastatic disease
• No concurrent cimetidine
• * Concurrent ranitidine or other drug from a different antiulcer class allowed
• No concurrent oral anticoagulation for treatment of thrombosis
• * Concurrent warfarin (1 mg) to maintain patency of central venous catheter allowed