Finding studies
Finding studies
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Lead
University of Chicago
With
Our objective is to examine the mechanism of the additive/synergistic properties of b2-adrenoceptor stimulation and corticosteroid receptor activation in: * Preventing neutrophil adhesion to specific endothelial ligands, e.g. ICAM-1 and * Undergoing activation as a consequence of this adhesion. We hypothesize that combination therapy with salmeterol + fluticasone (FP) will: * Augment the inhibition of adhesion of neutrophils obtained from the peripheral blood of study subjects in vitro, by blocking gIV-PLA2 translocation to the nuclear membrane as for eosinophils; * Augment the inhibition of transendothelial migration of neutrophils into airways of subjects with chronic obstructive pulmonary disease; * Augment the numbers and concentrations of pro-inflammatory products in the bronchoalveolar lavage fluid; and * Decrease the number of neutrophils in the bronchial tissue of endobronchial biopsies of treated patients.
Age
50–any
Sex
ALL
Healthy volunteers
Not accepted