Donor Stem Cell Transplant in Treating Young Patients With Relapsed or Refractory Solid Tumors

Inclusion Criteria

• •DISEASE CHARACTERISTICS:
• •Diagnosis of relapsed or refractory solid tumor, including, but not limited to, relapsed neuroblastoma, relapsed Ewing's sarcoma, and relapsed rhabdomyosarcoma
• •No isolated local disease recurrence at the site of the primary tumor \> 1 year after completion of prior therapy
• •No brain tumor or brain metastases
• •Related or unrelated hematopoietic stem cell donor available, meeting 1 of the following criteria:
• •* Matched for HLA-A, -B, -C, -DR, and -DQ (9/10 or 10/10 allelles) (marrow or peripheral blood)
• •* Matched for HLA-A, -B, and -DR (5/6 or 6/6 allelles) (cord blood)
• •* Cord blood specimen must contain ≥ 2 x 10 \^7 nucleated cells/kg body weight
• •PATIENT CHARACTERISTICS:
• •Age
• •30 and under
• •Performance status
• •ECOG 0-1 OR
• •Lansky 80-100%
• •Life expectancy
• •Not specified
• •Hematopoietic
• •Not specified
• •Hepatic
• •Bilirubin ≤ 3.0 mg/dL
• •Renal
• •Creatinine clearance ≥ 50 mL/min
• •Cardiovascular
• •Ejection fraction ≥ 50%
• •Pulmonary
• •DLCO ≥ 70% OR
• •O\_2 saturation ≥ 95% on room air
• •Other
• •Not pregnant
• •Negative pregnancy test
• •Fertile patients must use effective contraception
• •HIV negative
• •PRIOR CONCURRENT THERAPY:
• •Biologic therapy
• •Prior autologous stem cell transplantation allowed
• •Chemotherapy
• •Not specified
• •Endocrine therapy
• •Not specified
• •Radiotherapy
• •Not specified
• •Surgery
• •Not specified