AVONEX® Combination Trial - "ACT"

Exclusion Criteria

• •History of cirrhosis, chronic hepatitis, or currently active hepatitis
• •History of poorly-controlled hypertension, diabetes mellitus, or peptic ulcer disease
• •History of aseptic bone necrosis, osteoporosis, or osteoporosis-related bone fracture
• •History of steroid-induced psychosis.
• •History of or abnormal laboratory results indicating significant illness
• •History of severe allergic or anaphylactic reactions or known drug hypersensitivity or intolerance to MTX, IVMP, or AVONEX®.
• •History of allergy to albumin
• •History of any episode of suicidal ideation or severe depression within 3 months of the Screening Visit.
• •History of seizure within 3 months prior to the Screening Visit.
• •Diagnosis of primary progressive, secondary progressive, or progressive relapsing MS
• •MS relapse with onset within 60 days prior to the Baseline Visit
• •Any metallic or electronic material or device in the body, or condition that precludes the subject from undergoing MRI with gadolinium administration
• •A clinically significant infectious illness (e.g., cellulitis, abscess, pneumonia, septicemia) within 30 days of the Screening Visit
• •Abnormal blood tests, performed at the Screening Visit, which exceed any of the limits defined by the study.