Lenalidomide (Revlimid) to Treat Advanced Ocular Melanoma

Inclusion Criteria

• •1. All patients with stage IV ocular melanoma, who have measurable disease will be considered.
• •2. Patients must have histopathological documentation of ocular melanoma confirmed in the Laboratory of Pathology/National Cancer Institute (NCI) of the Clinical Center at the National Institutes of Health. This can be from tissue obtained outside the National Institutes of Health (NIH).
• •3. Patient must be Eastern Cooperative Oncology Group (ECOG) performance status of less than or equal to 2.
• •4. Patients must have a life expectancy of more than 3 months.
• •5. Hematological eligibility parameters (prescreen):
• •* Granulocyte count greater than 1,500/mm\^3
• •* Platelet count greater than 100,000/mm\^3
• •* If the creatinine is greater than 1.5 mg/dL, obtain a 24 hour urine collection. Creatinine clearance must be greater than 60 mL/min/1.73m\^2.
• •* Hepatic function: bilirubin (total) less than or equal to 2.0 mg/dl; Alanine aminotransferase (ALT) less than 10 x upper limit of normal; Aspartate aminotransferase (AST) less than 10 x upper limit of normal.
• •6. Patients must have recovered from any acute toxicity related to prior therapy or surgery, to a grade 1 or less unless specified above.
• •7. Patients must not have had prior surgery, chemotherapy, hormonal therapy, radiation therapy, or biological therapy, for at least 4 weeks prior to starting study medication. Patients who were receiving mitomycin C, nitrosoureas, or carboplatin must be 6 weeks from the last administration of chemotherapy.
• •8. Patients must not have an acute, critical illness, including a serious untreated infection.
• •9. Patients must be willing to return to the National Institutes of Health (NIH) for follow-up visits.
• •10. All patients who are sexually active and able to conceive will be required to use contraception during treatment with lenalidomide.
• •Only two criteria are allowed by the Food and Drug Administration (FDA) for the status of not of child bearing potential: hysterectomy or menopause for 24 consecutive months. Women of child bearing potential will be required to use two methods of birth control, one highly effective method and one additional method, at the same time during treatment and for one month after the completion of lenalidomide treatment. These methods must be used for at least four weeks before starting lenalidomide, during treatment, and for at least four weeks following the last dose of lenalidomide. Acceptable forms of birth control include:
• •Intrauterine device (IUD)
• •Latex condom
• •Hormonal (Birth control pills, injections, implants)
• •Diaphragm
• •Tubal Ligation
• •Cervical cap
• •Partner's vasectomy
• •Two barrier methods may be used if the physician agrees that the highly effective methods are medically contraindicated.
• •Women of childbearing potential must have a negative urine pregnancy test 24 hours prior to the start of lenalidomide.
• •Men who are sexually active must agree to use latex condoms.
• •Patients must be able to understand and sign informed consent form.
• •Patients must be greater than or equal to 18 years of age.