More than 2 prior skeletal related events (SRE)

Known brain metastases

Prior history or current evidence of osteonecrosis/osteomyelitis of the jaw

Active dental or jaw conditions which requires oral surgery

Non-healed dental/oral surgery

Prior administration of AMG 162

Evidence of impending fracture in weight bearing bones

Pregnancy or breastfeeding. Subjects must be surgically sterile, postmenopausal, or must agree to use effective contraception during the study.

Study of AMG 162 in Subjects With Advanced Cancer Currently Being Treated With Intravenous (IV) Bisphosphonates