Dasatinib (BMS-354835) Versus Imatinib Mesylate in Subjects With Chronic Myeloid Leukemia

Exclusion Criteria

• •Women who are unwilling or unable to use an acceptable method to avoid pregnancy for the entire study period for a least 1 month before and at least 3 months after the completion of the study.
• •Women using a prohibited contraceptive method.
• •Women who are pregnant or breastfeeding.
• •Men whose sexual partners are women who are of childbearing potential, and who are unwilling or unable to use an acceptable method to avoid pregnancy of his partner for the entire study period as outlined above.
• •Prior treatment with imatinib at a dose \>600 mg/day.
• •Subjects who have previously identified specific BCR-ABL mutations.
• •Previous diagnosis of accelerated phase or blast crisis CML.
• •Intolerance to imatinib at any dose.
• •Subjects who are eligible and willing to undergo transplantation during the screening period.
• •Serious uncontrolled medical disorder or active infection.
• •Uncontrolled or significant cardiovascular disease.
• •Uncontrolled hypertension.
• •Dementia or altered mental status.
• •Evidence of organ dysfunction.
• •Use of imatinib within 7 days.
• •Use of interferon or cytarabine within 14 days.
• •Use of a targeted small molecule anticancer agent within 14 days.
• •Subjects taking certain medications that are accepted to have a risk of causing Torsades de Pointes.
• •Subjects taking medications that irreversibly inhibit platelet function or anticoagulants.
• •Prior therapy with BMS-354825.