Safety and Efficacy of Avonex in Subjects With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)

Exclusion Criteria

• •Associated systemic disorder that might cause neuropathy.
• •History of, or abnormal laboratory results indicative of any significant major disease or known drug hypersensitivity that, in the opinion of the investigator, would preclude the administration if IFN-beta or participation in this study.
• •Subjects with diabetes mellitus will not be eligible, unless they satisfy both of the following requirements: a) their diabetes is well-controlled, with no retinopathy or nephropathy, having been identified during the ongoing care of their diabetes; and b) they have a normal sensory nerve action potential (SNAP) amplitude recorded in the sural nerve on at least one side of the body identified during electrophysiology (EP) testing documented in their medical record.
• •Abnormal screening or baseline blood tests that the investigator deems clinically significant
• •History of a seizure disorder prior to baseline (Visit 1, Week 0).
• •History of suicidal ideation within 3 months prior to Baseline Visit (Week 0) or an episode of severe depression within 3 months prior to Baseline Visit (Week 0).
• •Pure motor syndrome fulfilling criteria for multifocal motor neuropathy with conduction block.
• •Pure sensory CIDP, or any other variant of CIDP without motor involvement
• •Serious local infection or systemic infection within the 6 months prior to Screening.
• •Use of IFN-beta at any time, use of plasma exchange, plasmapheresis, or any other immunosuppressant (with the exception of oral or non-systemic corticosteroids) within 6 months prior to Screening.
• •History of intolerance to acetaminophen (paracetamol), ibuprofen, naproxen, and/or aspirin that would preclude use of at least one of these during the study.
• •For female subjects, unless postmenopausal or surgically sterile, unwillingness to practice effective contraception, as defined by the Investigator, during the study.
• •Female subjects considering becoming pregnant while in the study
• •Female subjects who are currently pregnant or breast-feeding.
• •* This list is not exhaustive and there may be additional exclusions