Effects of Lithium and Divalproex'on Brain-Derived Neurotrophic Factor in Huntington's Disease

Exclusion Criteria

• •1. Patient has a history of any medical condition such as diabetes, cardiac disease, renal impairment, liver disease, pancreatitis and other chronic medical problems that can reasonably be expected to subject the patient to unwarranted risk;
• •2. Patient has clinically significant laboratory abnormalities that would preclude administration of lithium and divalproex;
• •3. Patient is taking a prohibited concomitant medication;
• •4. Patient has not been using an adequate contraceptive method for the last 30 days or unwilling to continue contraception throughout the study, or is not at least one year post menopausal (if female);
• •5. Patient is pregnant or breastfeeding;
• •6. Patient has participated in a clinical study with an investigational drug within the last 30 days;
• •7. Patient has a condition (such as active drug or alcohol abuse) that, in the opinion of the investigators, would interfere with compliance or safety;
• •8. Patient has known hypersensitivity to lithium or divalproex;
• •9. Patients inability to swallow tablets or to comply with medication schedule;
• •10. Patient and / or caregiver are unwilling to sign an informed consent or to comply with protocol requirements;
• •11. Patient is unwilling to have lumbar puncture.
• •12. Patient with history of severe depression, or past suicide attemps.