Irbesartan Versus Placebo in Combination With Ramipril for Treatment of Albuminuria

Inclusion Criteria

• •Subjects must be willing and able to provide written informed consent.
• •Males and Females 55 years of age and over
• •Subjects must have a history of high blood pressure and elevated cardiovascular risk defined as one of the following:
• •1. Diabetes
• •2. Advanced coronary disease defined as previous myocardial infarction. Active angina, or significant changes in tests indicating ischemia
• •3. Artery disease in the legs, limiting walking capacity and/or blood flow in the legs
• •4. Stroke occurring more than 3 months prior to the screening visit
• •All subjects must also have albuminuria (protein in the urine) that is confirmed by a urine test at the first study visit.
• •All subjects must currently be treated with a class of drugs called ACE inhibitors (e.g., benazepril, captopril, enalapril, lisinopril, moexipril, ramipril, quinapril, perindopril) for at least 2 months prior to the study.
• •Women of childbearing potential (WOCBP) must be using adequate methods of contraception to avoid pregnancy throughout the study and four weeks after the study ends.