Evidence of active brain metastases

The only evidence of metastasis is lytic or blastic bone metastases

Pre-existing peripheral neuropathy of NCI Toxicity Criteria Scale of grade greater than 2

Received radiotherapy in last 4wks, except if to a non-target lesion only

Clinically significant concurrent illness

Investigator's opinion that patient unlikely to complete study

Cytotoxic chemotherapeutic agent treatment or investigational drug within previous 4wks

History of allergy/hypersensitivity to study drug

Serious Medical Risk Factors determine by the investigator

Trial of ABI-007 in Previously Treated Patients With Metastatic Melanoma