MDX-010 in Treating Patients With Recurrent or Refractory Lymphoma

Exclusion Criteria

• •Known standard therapy for the patient's disease that is potentially curative or definitely capable of extending life expectancy
• •Eastern Cooperative Oncology Group (ECOG) performance status (PS) 2, 3, or 4
• •Any uncontrolled infection, hepatitis C virus (HCV)+ (unless HCV ribonucleic acid \[RNA\]-negative by polymerase chain reaction \[PCR\]) or hepatitis B surface antigen (HBsAg)+, or human immunodeficiency virus (HIV) positive patients or patients with known immune deficiency states
• •Previous MDX-010 therapy regardless of interval since last treatment
• •Prior treatment with fludarabine or 2-chlorodeoxyadenosine =\< 12 months prior to registration
• •Failure to fully recover from acute, reversible effects of prior chemotherapy regardless of interval since last treatment
• •New York Heart Association classification III or IV or a history of angina pectoris requiring active treatment
• •Clinical evidence of central nervous system involvement by lymphoma
• •Any of the following:
• •* Pregnant women
• •* Nursing women
• •* Men or women of childbearing potential who are unwilling to employ adequate contraception (condoms, diaphragm, birth control pills, injections, intrauterine device \[IUD\], or abstinence, etc.)
• •Other concurrent chemotherapy, immunotherapy, radiotherapy, or any ancillary therapy considered investigational (utilized for a non-Food and Drug Administration \[FDA\]-approved indication and in the context of a research investigation)
• •Diagnosis of small lymphocytic lymphoma/chronic lymphocytic leukemia (CLL)
• •Any requirement for concurrent steroid therapy, including use of inhaled steroids for asthma
• •History of autoimmune disease requiring systemic therapy with immunosuppressive drugs, including but not limited to rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, multiple sclerosis, or psoriasis
• •Antinuclear antibody (ANA) titer or rheumatoid factor titer \> 3x institutional ULN