Imatinib Mesylate in Treating Patients With Locally Recurrent or Metastatic Dermatofibrosarcoma Protuberans

Inclusion Criteria

• •Patients must have histologically confirmed diagnosis of either dermatofibrosarcoma protuberans (DFSP) or transformed fibrosarcomatous DFSP; patients with transformed fibrosarcomatous DFSP may have primary, locally recurrent or metastatic disease; patients with DFSP must have locally recurrent or metastatic disease OR primary disease for which complete excision with a wide margin (\> 1-2 cm) would result in unacceptable cosmetic disfigurement or functional impairment
• •Patients must have measurable disease; x-rays, scans or physical examinations used for tumor measurement must have been completed within 28 days prior to registration; x-rays, scans or other tests for assessment of non-measurable disease must have been performed within 42 days prior to registration; all disease must be assessed
• •Pathology materials must be submitted for review; failure to submit pathology materials will render the patient ineligible
• •Patients must be willing to have blood samples submitted for testing of drug levels; also, it is strongly recommended that patients submit fresh/frozen tumor tissue that will yield 0.5 grams (0.5 cubic centimeters) for molecular correlative studies related to the PDGFR pathway
• •Patient must not have had chemotherapy, biologic therapy or investigational agents for this tumor within 28 days prior to registration
• •Patients may have received prior major surgery for this disease; at least 14 days must have elapsed since the surgery and the patient must have recovered from all side effects associated with surgery; biopsy of dermatofibrosarcoma protuberans is not considered major surgery and a 14-day delay after biopsy is not required
• •Prior radiotherapy is allowed, provided at least four weeks have elapsed since the last treatment, there is evidence of progressive disease within or measurable disease outside of the radiation field, and the patient must have recovered from all associated toxicities at the time of registration
• •Patients must have Zubrod performance status of =\< 2
• •WBC \>= 2,000/uL
• •ANC \>= 1,500/uL
• •Platelets \>= 100,000/uL
• •Serum bilirubin =\< 1.5 x institutional upper limit of normal (IULN)
• •Serum transaminase (SGOT or SGPT) must be =\< 2.5 x IULN
• •Serum albumin must be \>= 2.5 mg/dl
• •Patients must not be taking therapeutic doses of coumadin (Warfarin) at the time of registration; patients requiring therapeutic anticoagulation may use heparin, low molecular weight heparin or other agents; mini-dose coumadin (1 mg orally every day as prophylaxis is allowed