Cisplatin and Flavopiridol in Treating Patients With Advanced Ovarian Epithelial Cancer or Primary Peritoneal Cancer

You may be eligible if

• Histologically confirmed ovarian epithelial or primary peritoneal cancer:
• Advanced disease
• Meets at least 1 of the following criteria:
• * Measurable disease;
• * Evaluable disease plus CA 125 \>= 2 times post-treatment nadir
• Treated with 1, and only 1, prior platin-containing chemotherapy regimen (e.g., paclitaxel or carboplatin-based) for ovarian epithelial or primary peritoneal cancer
• Prior treatment with the same regimen at first relapse allowed;
• * No more than 3 total chemotherapy regimens allowed provided exactly 1 has been platin-containing;
• * Must also have platin-resistant disease as defined for Group 1;
• * Rechallenge with a single regimen upon progression after a hiatus from therapy counts as a single regimen
• Group 1, meeting 1 of the following criteria:
• * Patients who relapse during or \< 6 months after completion of post-debulking chemotherapy;
• * "Platinum sensitive" patients in second relapse after having been treated/rechallenged with their initial regimen upon first relapse
• Group 2 (Closed to accrual as of 3/10/06):
• * Patients who relapse \>= 6 months after completion of post-debulking chemotherapy and are not retreated with the same or a different regimen
• No CNS metastases
• Performance status:
• * ECOG 0-2
• Hematopoietic:
• * Absolute neutrophil count \>= 1,500/mm3;
• * Platelet count \>= 100,000/mm3;
• * Hemoglobin \>= 10 g/dL (Note: May be supported with transfusion, epoetin alfa, or darbepoetin alfa)
• Hepatic:
• * AST =\< 2.5 times upper limit of normal (ULN);
• * Alkaline phosphatase =\< 2.5 times ULN;
• * Bilirubin =\< 1.5 times ULN
• Renal:
• * Creatinine =\< 1.5 times ULN
• Cardiovascular:
• * No cardiac arrhythmia;
• * No cardiac failure
• Not pregnant or nursing
• Negative pregnancy test
• More than 3 weeks since prior chemotherapy (6 weeks for nitrosoureas)
• More than 3 weeks since prior radiotherapy
• Recovered from all prior therapy
• Fertile patients must use effective contraception
• No other malignancy within the past 5 years except non-melanoma skin cancer or carcinoma in situ of the cervix
• No diabetes
• No peripheral neuropathy \>= grade 2
• No baseline diarrhea (\>= 4 stools/day)
• No uncontrolled infection
• No other concurrent uncontrolled serious medical condition
• No concurrent routine colony-stimulating factors