Laboratory Values of:

Serum creatinine \> 1.8 mg/dL; unless 24-hour urine creatinine clearance is ≥ 70 mL/min

Serum total bilirubin \> 1.5 times the upper limit of normal

ALT (formerly SGPT) \> 1.5 times the upper limit of normal

Alkaline phosphatase \> 1.5 times the upper limit of normal

Absolute neutrophil count (ANC) \< 1500/L

Platelet count \< 100,000/L

3+ or greater proteinuria on urinalysis

and

Squamous Cell Carcinoma of the Head and Neck arising from a primary site in the oral cavity or nasopharynx

Distant metastases

Prior history of cancer at any site treated with radiotherapy and/or chemotherapy

History of SCCHN diagnosed within 5 years of current diagnosis

Motexafin Gadolinium With Chemotherapy and Radiation Therapy for the Treatment of Advanced Head and Neck Cancer