Bupropion and Counseling With or Without Contingency Management to Enhance Smoking Cessation in Treating Cancer Survivors Who Continue to Smoke

Inclusion Criteria

• •DISEASE CHARACTERISTICS:
• •Diagnosis of cancer at least 6 months before study entry
• •* No carcinoma in situ of the cervix, basal cell or squamous cell skin cancer, or CNS tumor
• •Smoking history of at least 2 years
• •* Smoked cigarettes daily for the past 30 days
• •Completed prior cancer treatment at least 6 months, but no more than 5 years before study entry
• •* Concurrent tamoxifen allowed
• •PATIENT CHARACTERISTICS:
• •Age
• •18 and over
• •Performance status
• •Not specified
• •Life expectancy
• •Not specified
• •Hematopoietic
• •Platelet count ≥ 100,000 - 450,000/mm\^3
• •WBC ≥ 3,000/mm\^3
• •Hepatic
• •AST and ALT ≤ 2 times upper limit of normal
• •Bilirubin ≤ 2.0 mg/dL
• •Renal
• •Creatinine \< 2.0 mg/dL
• •Cardiovascular
• •No unstable cardiovascular disease, including any of the following:
• •* High-grade atrioventricular block
• •* Neurocardiogenic syncope
• •* Unstable angina
• •* Uncompensated congestive heart failure
• •* Poorly controlled hypertension
• •Other
• •Not pregnant or nursing
• •Negative pregnancy test
• •Able to undergo peripheral blood draw
• •* No port-a-cath or Hickman catheters
• •Planning to reside in the Washington D.C. metro area for at least 1 year after study entry
• •Willing to undergo urine testing for cotinine levels and breath testing for carbon monoxide monitoring
• •No significant physical or psychological disability that would preclude study participation
• •No known allergy to bupropion
• •Baseline urine drug screen negative
• •* Prescribed pain medication allowed
• •None of the following predisposing factors that may increase the risk of seizures with bupropion use:
• •* History of seizures
• •* Alcohol use \> 4 oz/day
• •* History of closed head injury
• •* History of an eating disorder
• •* CNS infection
• •No poorly controlled diabetes
• •PRIOR CONCURRENT THERAPY:
• •Biologic therapy
• •Not specified
• •Chemotherapy
• •Not specified
• •Endocrine therapy
• •See Disease Characteristics
• •Radiotherapy
• •Not specified
• •Surgery
• •Not specified
• •Other
• •At least 2 years since prior alcohol abuse or substance abuse therapy (except for tobacco use or dependence)
• •More than 14 days since prior monoamine oxidase (MAO) inhibitor
• •No concurrent MAO inhibitor
• •No concurrent bupropion (Wellbutrin® or Wellbutrin SR®)
• •No concurrent alcohol or substance abuse disorder treatment
• •No concurrent nicotine replacement therapy
• •No concurrent medications that lower seizure threshold (e.g., theophylline or short-acting benzodiazepines)
• •No use of tobacco products (more than 1 time per week) other than cigarettes