Low-Dose Testosterone in Improving Libido in Postmenopausal Female Cancer Survivors

Inclusion Criteria

• •DISEASE CHARACTERISTICS:
• •History of cancer
• •* No active disease
• •Currently has a sexual partner
• •Reports a decrease in sexual desire or libido and would like an intervention for it
• •* Defined as a score of less than 8 on the numerical analogue scale
• •PATIENT CHARACTERISTICS:
• •Age
• •See Menopausal status
• •Sex
• •Female
• •Menopausal status
• •Postmenopausal, defined as the following:
• •* Surgically induced menopause OR absence of a period for at least 12 months (naturally or treatment-induced)
• •Performance status
• •ECOG 0-1
• •Hematopoietic
• •WBC ≥ 2,500/mm\^3
• •Platelet count ≥ 100,000/mm\^3
• •Hemoglobin ≥ 10 g/dL
• •No untreated anemia
• •Hepatic
• •SGOT ≤ 1.5 times upper limit of normal (ULN)
• •No known liver disease
• •Renal
• •Creatinine ≤ 1.5 times ULN
• •No renal dysfunction
• •Cardiovascular
• •No coronary artery disease
• •No congestive heart failure
• •Other
• •No untreated hypothyroidism
• •No diabetes
• •No major depressive disorder requiring treatment
• •PRIOR CONCURRENT THERAPY:
• •Chemotherapy
• •Concurrent cytotoxic chemotherapy (e.g., tamoxifen or aromatase inhibitors) allowed
• •Endocrine therapy
• •No prior testosterone
• •No prior androgen agents for libido
• •Concurrent selective estrogen receptor modulators allowed
• •Concurrent vaginal estrogen allowed provided it was initiated ≥ 1 month ago and continued at the same dose during study participation
• •Radiotherapy
• •Concurrent radiotherapy allowed
• •Surgery
• •No prior major pelvic surgery resulting in anatomical changes to the vaginal anatomy
• •* Prior hysterectomy allowed
• •Other
• •Concurrent antidepressants for postmenopausal mood or hot flashes allowed provided patient is on a stable dose that will not change within the next 8 weeks
• •No concurrent anticoagulants or propanolol
• •* Concurrent anticoagulants for central or peripheral line maintenance (e.g., warfarin 1 mg daily or heparin flushes) allowed
• •No other concurrent treatment for decreased libido