CC-8490 in Treating Patients With Recurrent or Refractory High-Grade Gliomas

You may be eligible if

• DISEASE CHARACTERISTICS:
• Histologically confirmed supratentorial malignant glioma, including any of the following:
• * Glioblastoma multiforme
• * Gliosarcoma
• * Anaplastic astrocytoma
• * Anaplastic oligodendroglioma
• * Anaplastic mixed oligoastrocytoma
• * Malignant glioma/astrocytoma not otherwise specified OR
• Clinical and radiographic diagnosis of progressive low-grade glioma
• Radiographically diagnosed infiltrating brain stem gliomas not amenable to biopsy allowed
• Recurrent or progressive disease as determined by 1 of the following:
• * CT scan or MRI within the past 21 days
• * Biopsy within the past 12 weeks
• Failed prior radiotherapy
• PATIENT CHARACTERISTICS:
• Age
• 18 and over
• Performance status
• Karnofsky 60-100%
• Life expectancy
• More than 8 weeks
• Hematopoietic
• Granulocyte count at least 1,500/mm\^3
• Platelet count at least 100,000/mm\^3 (transfusion independent)
• Hemoglobin at least 8 g/dL (transfusion allowed)
• Hepatic
• Bilirubin no greater than 1.5 mg/dL
• AST and ALT no greater than 2 times upper limit of normal
• No significant active hepatic disease that would preclude study participation
• Renal
• Creatinine no greater than 1.5 mg/dL OR
• Creatinine clearance at least 60 mL/min
• No significant active renal disease that would preclude study participation
• Cardiovascular
• No significant active cardiac disease that would preclude study participation
• Other
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception during and for 2 months after study participation
• No other malignancy within the past 3 years except nonmelanoma skin cancer or carcinoma in situ of the cervix
• No significant active psychiatric disease that would preclude study participation
• No other condition or laboratory abnormality that would preclude study participation
• Able to swallow capsules whole
• PRIOR CONCURRENT THERAPY:
• Biologic therapy
• At least 2 weeks since prior interferon
• No concurrent immunotherapy
• Chemotherapy
• At least 2 weeks since prior vincristine
• At least 3 weeks since prior procarbazine
• At least 4 weeks since prior temozolomide or carboplatin
• At least 6 weeks since prior nitrosoureas
• No other concurrent anticancer chemotherapy
• Endocrine therapy
• At least 2 weeks since prior tamoxifen
• Concurrent steroids allowed provided dose has been stable for at least 5 days prior to study enrollment
• Radiotherapy
• See Disease Characteristics
• At least 2 weeks since prior radiotherapy
• No concurrent radiotherapy
• Surgery
• At least 2 weeks since prior resection of a recurrent or progressive tumor
• Other
• At least 2 weeks since other prior non-cytotoxic therapy
• At least 4 weeks since other prior cytotoxic therapies
• More than 28 days since prior experimental study drugs
• No other concurrent investigational agents