A Pilot Study of OSI-461 in Patients With Chronic Lymphocytic Leukemia (CLL)

Exclusion Criteria

• •Other active malignancy or history of treatment of any malignancy (excluding non-melanoma skin cancer) within the previous three years.
• •History of other malignancy which could affect the diagnosis or assessment of OSI-461.
• •Previous therapy for CLL.
• •Use of an investigational medication or device within one month of initiating study therapy.
• •Concurrent immunotherapy.
• •Use of steroids at the time of enrollment (patients who require steroids after enrollment may remain on study).
• •Any condition or any medication which may interfere with the conduct of the study.
• •Serious uncontrolled intercurrent medical or psychiatric illness, including serious infection.
• •Evidence of CNS involvement.
• •Pregnant or nursing women.