Evaluating the Use of SR34006 Compared to Warfarin or Acenocoumarol in Patients With Atrial Fibrillation (AMADEUS)

Exclusion Criteria

• •Legal lower age limitations (country specific)
• •Indication for VKA other than AF, including prosthetic heart valves, venous thromboembolism, and planned cardioversion
• •Transient AF caused by a reversible disorder
• •Active bleeding or high risk of bleeding
• •Recent (\<15 days) or anticipated invasive procedures with potential for uncontrolled bleeding, including major surgery
• •Participation in another pharmacotherapeutic study within the prior 30 days
• •Creatinine clearance \<10 mL/min, severe hepatic disease, or bacterial endocarditis
• •Uncontrolled hypertension: systolic blood pressure \> 180 mm Hg and/or diastolic blood pressure \> 110 mm Hg
• •Pregnancy or childbearing potential without proper contraceptive measures
• •Breastfeeding
• •Any other contraindication listed in the labeling of warfarin or acenocoumarol