Delaying Alzheimer Disease Symptoms With Anti-Inflammatory Drugs

Exclusion Criteria

• •Possible or probable Alzheimer Disease (AD) or other dementia
• •Neurologic or other physical illness that could produce cognitive deterioration
• •History of transient ischemic attacks (TIAs), carotid bruits, or lacunes on an MRI scan
• •History of myocardial infarction within the previous year or unstable cardiac disease
• •Uncontrolled hypertension (systolic BP \> 170 or diastolic BP \> 100)
• •History of significant liver disease, pulmonary disease, diabetes, or cancer
• •DSM-IV criteria for major psychiatric disorders within the previous 2 years
• •Past or present history of alcoholism or drug dependence
• •Untreated depression as determined by a Hamilton Depression Rating Scale (HAM-D) score of 12 or more
• •Drugs that may significantly affect psychometric test results
• •Centrally active beta-blockers, narcotics, clonidine, anti-Parkinsonian medications, antipsychotics, benzodiazepines, systemic corticosteroids, medications with significant cholinergic or anticholinergic effects, anti-convulsants, warfarin, vitamins other than the standard multivitamin supplement, ginkgo biloba, and any nutraceuticals. Occasional chloral hydrate use will be allowed, but discouraged, for insomnia.
• •Investigational drugs within the previous month or longer, depending on drug half-life
• •Contraindication for MRI scan (e.g., metal in body, claustrophobia)