Vitamin K and Bone Turnover in Postmenopausal Women

You may be eligible if

• Female, 5 years postmenopause.
• Ambulatory.
• Community dwelling.
• Able to ingest calcium and vitamin D supplements.
• Willing to restrict vitamin K intake.
• Stable thyroid dose if appropriate.
• No history of hyperthyroidism, hyperparathyroidism or other metabolic bone diseases.
• Absence of hardware in hip and spine.
• History of malignancy within the last five years.
• Not currently using coumadin or warfarin.
• Vitamin D supplements must be less than 800 IU daily.
• Have not used estrogen or other bone-altering medications (see list in study description) within the last year.
• No history of liver disease or malabsorption.
• No known allergy to vitamin K.
• Have not participated in an investigational drug trial within the last month.