Total-Body Irradiation, Cyclophosphamide, and Stem Cell Transplantation in Treating Patients With Hematologic Cancer

You may be eligible if

• DISEASE CHARACTERISTICS:
• Diagnosis of hematological malignancy, including any of the following:
• * Chronic myeloid leukemia
• * Acute myeloid leukemia
• * Acute lymphocytic leukemia
• * Myelodysplastic syndromes
• * Lymphoma
• Unlikely to respond to conventional treatment and would benefit from hematopoietic stem cell transplantation
• No bulky tumor mass requiring additional involved field radiotherapy
• No large body burden of tumor cells requiring cytoreductive chemotherapy before total body irraditation and cyclophosphamide
• Undergoing conditioning for transplantation at the University of Washington Medical Center
• Availability of 1 of the following types of allogeneic donors:
• * HLA-identical family members
• * Unrelated donors
• * Allele match (match grade 1)
• * One allele mismatch for A, B, C, DRB1 or DQB1 (match grades 2.1 or 2.2)
• PATIENT CHARACTERISTICS:
• Age
• 18 to 65
• Performance status
• Not specified
• Life expectancy
• Not severely limited by diseases other than malignancy
• Not moribund
• Hematopoietic
• Not specified
• Hepatic
• Bilirubin no greater than 1.2 mg/dL
• No cirrhosis
• No hepatic fibrosis with bridging
• Renal
• Creatinine no greater than 1.2 mg/dL
• Cardiovascular
• No coronary artery disease
• No congestive heart failure requiring therapy
• Pulmonary
• Oxygen saturation at least 93% (on room air)
• Other
• Not pregnant or nursing
• Fertile patients must use effective contraception
• HIV negative
• No concurrent infection requiring systemic antibiotic or antifungal therapy
• PRIOR CONCURRENT THERAPY:
• Biologic therapy
• No prior hematopoietic stem cell transplantation
• Chemotherapy
• See Disease Characteristics
• Endocrine therapy
• Not specified
• Radiotherapy
• See Disease Characteristics
• No prior radiotherapy to the liver or adjacent organs
• Surgery
• Not specified
• Other
• No concurrent aspirin or nonsteroidal anti-inflammatory medications such as ibuprofen (e.g., Motrin® or Advil®)
• No other concurrent phase I study enrollment