A Study to Determine if Antibiotics Prevent Infection in the Pancreas of Patients Where Part of the Pancreas Has Died

Exclusion Criteria

• •Received an investigational drug or device within 30 days prior to entering study.
• •Received \> 48 hours of antibiotic therapy between onset of symptoms of pancreatitis and diagnosis of necrotizing pancreatitis.
• •The subject has known or suspected anaphylactic or other type 1 (immediate) hypersensitivity reactions to cephalosporins, penicillins or carbapenems.
• •The subject is receiving, or will require, probenecid therapy.
• •The subject is neutropenic (absolute neutrophil count \< 1000/mm 3).
• •The subject has cirrhosis, severity of Child's grade C.
• •There is not a commitment on the part of the clinical care team, the subject, or the subject's family to full, aggressive support including operative intervention if needed.
• •The subject is a pregnant and/or nursing female