Adjuvant Hepatic Arterial Infusion and Combination Chemotherapy in Treating Patients With Resectable Hepatic Metastases From Colorectal Cancer

Inclusion Criteria

• •History of histologically confirmed colorectal adenocarcinoma metastatic to the liver with no clinical or radiographic evidence of extrahepatic disease. Confirmation of diagnosis must be performed at MSKCC.
• •Potentially completely resectable hepatic metastases without current evidence of other metastatic disease.
• •Abdominal and pelvic CT scans and chest CT or x-ray within 6 weeks prior to registration. (MRI of abdomen may be substituted for CT of abdomen.)
• •Lab values within 14 days prior to registration:
• •WBC ≥ 3.0 K/ul
• •ANC \>1.5 K/ul
• •Platelets ≥ 100 K/ul
• •Total bilirubin ≤ 1.5 mg/dl.
• •Prior chemotherapy is acceptable if last dose given ≥ 3 weeks prior to registration to this study.
• •KPS ≥ 60%
• •Signed informed consent.