A Safety, Tolerability and Efficacy Study of E7070 in Patients With Renal Cell Carcinoma

Exclusion Criteria

• •Woman who are pregnant or breastfeeding. Women of childbearing potential with either a positive pregnancy test at screening or no pregnancy test. Women of childbearing potential unless (1) surgically sterile or (2) using adequate contraceptive measures (postmenopausal women must be amenorrheic for at least 12 months to be considered of non-childbearing potential).
• •Fertile male subjects not willing to use contraception and whose female partners are not under adequate contraceptive protection.
• •Known CNS metastases (if clinical suspicion of CNS metastases exists appropriate imaging must be performed prior to study entry).
• •Prior treatment with chemotherapy (there is no restriction on prior epidermal growth factor directed therapy).
• •Severe and uncontrolled cardiac or cardiovascular abnormalities.
• •Severe uncontrolled intercurrent infections.
• •Subjects with organ allografts.
• •Any of the following abnormal screening hematological values: Hemoglobin (Hb) \<9g /dL (6 mmol/L), Neutrophils \<1.5 x 10\^9/L, Platelets \<100 x 10\^9/L.
• •Blood transfusions or growth factors to aid hematological recovery within 2 weeks prior to starting study treatment.
• •Any of the following abnormal screening liver function tests: serum bilirubin \>= 1.5 x upper normal limit (ULN), alanine aminotransferase (ALAT) and aspartate aminotransferase (ASAT) \>= 2.5 x ULN (unless related to liver metastases in which case \>= 5 x ULN).
• •The following abnormal screening renal function tests: either a serum creatinine \> 1.5 x ULN or a creatinine clearance (estimated from serum creatinine) \< 40 mL/minute.
• •Prior radiotherapy (except palliative).
• •Participation in any investigational drug study or immunotherapy within 4 weeks preceding treatment start.
• •History of hypersensitivity to sulphonamides.
• •Any concurrent or previous malignancy of a different tumor type within 5 years of starting E7070 treatment except for adequately treated non-melanoma skin cancer or cervical intra-epithelial neoplasia.
• •Significant disease, which in the Investigator's opinion would exclude the patient from the study.
• •Surgically resectable metastatic disease.
• •Legal incapacity.