Trial of High-dose Urso in Primary Sclerosing Cholangitis

You may be eligible if

• Chronic cholestatic disease of at least six months' duration.
• Serum alkaline phosphatase at least 1 ½ times the upper limits of normal.
• Retrograde, operative, percutaneous, or magnetic resonance cholangiography demonstrating intrahepatic and/or extrahepatic biliary duct obstruction, beading, or narrowing consistent with PSC within one year of the study entry.
• Liver biopsy in the previous one year which is available for review and compatible with the diagnosis of PSC. Compatible biopsy features include fibrous cholangitis, ductopenia with periportal inflammation and biliary fibrosis.