A Blinded Study Conducted at Multiple Centers Evaluating Various Doses of an Investigational Agent (BO-653) Against Placebo, for Safety and Effectiveness in Preventing Post-Angioplasty Blood Vessel Re-Closure (Restenosis) in Stented Vessels.

Exclusion Criteria

• •The study physician must assure you:
• •Have not had any coronary intervention within 30 days before, and for an expected 30 days after stenting.
• •Have not had a cerebrovascular accident or transient ischemic attack within 90 days prior to stent placement.
• •Have not had stent procedure as a bridge to non-emergency planned bypass.
• •Have not had a stent placed within the target vessel less than 9 months ago, or less than 5mm from the closest edge of an adjacent lesion.
• •Do not have an unprotected left main coronary artery disease.
• •Do not have a left ventricular ejection fraction of \< 30%.
• •Do not have a target lesion that is located at the ostium (\< 2mm from origin of left anterior descending, right coronary artery, or circumflex vessel), involves a side branch ≥2.0mm diameter, is moderately to severely calcified, or requires use of an atherectomy device.
• •Have not had a heart transplant.
• •Do not have a 12-lead ECG with a QTc interval pre- or post stent placement ≥ 460 msec (males), or ≥ 470 msec (females).
• •Do not have any medical, surgical or psychiatric condition, or be medical unstable as would prevent you from safely participating in the trial.
• •Do not have clinically relevant bleeding, clotting, or immune disorders or be intolerant of platelet inhibitors and/or anticoagulants.
• •Are not taking rifampin, carbamazepine, phenobarbitol, cyclophosphamide, ifosfamide, artemisinin, mephenytoin, phenytoin, or cholestyramine.
• •Have no clinically significant laboratory abnormality (specified: creatinine ≥ 2.2 mg/dl, liver function tests ≥ 2.0 times the upper limit of normal).
• •Have not participated in any investigational study within past 30 days.
• •Are not allergic or intolerant to soybean products.
• •Are not taking vitamin E in excess of 150 I.U. per day and that you are unwilling to stop.