Interleukin-12 and Interleukin-2 in Treating Patients With Refractory or Recurrent Neuroblastoma

You may be eligible if

• Diagnosis of neuroblastoma
• * Histologically confirmed disease AND/OR disease defined by tumor cells in the bone marrow and elevated urinary catecholamine metabolites
• Persistent and/or refractory disease, with at least 1 of the following:
• * Biopsy-proven residual disease at least 12 weeks after myeloablative therapy
• * Progressive disease after nonmyeloablative or myeloablative therapy
• Recurrent disease, evidenced by any of the following:
• * Biopsy-proven recurrent soft tissue disease
• * Metaiodobenzylguanidine (MIBG)-positive lesions visible on any other imaging modality or repeat MIBG obtained 2-4 weeks or more apart
• * Histologically confirmed bone marrow disease
• * Progressive or stable disease after at least 1 prior standard salvage regime
• No clinically significant pleural effusion
• ECOG 0-1
• Life expectancy \>= 12 weeks
• Hepatitis A antibody negative
• Hepatitis B surface antigen negative
• * Positive hepatitis B titer allowed if patient has been immunized and has no history of disease
• Hepatitis C virus negative
• No history of congenital or acquired coagulation disorder
• Cardiac function normal by ECG
• No dyspnea at rest
• No exercise intolerance
• Oxygen saturation at least 94% by pulse oximetry
• DLCO greater than 60% of predicted
• FEV1 greater than 70% of predicted
• Negative pregnancy test
• Skull-based bony lesions without space-occupying intracranial extension are allowed
• No prior or concurrent intracranial metastatic disease to the brain parenchyma
• Not pregnant or nursing
• Fertile patients must use effective barrier contraception during and for at least 2 months after study
• No prior hematologic malignancy (including leukemia or lymphoma)
• No history of malignant hyperthermia
• No prior or concurrent autoimmune disease
• No positive direct Coombs testing
• No history of ongoing or intermittent bowel obstruction
• No active infection or other significant systemic illness
• More than 2 weeks since prior fenretinide
• More than 2 weeks since prior 13-cis-retinoic acid
• More than 2 weeks since prior filgrastim (G-CSF) or sargramostim (GM-CSF)
• More than 2 weeks since prior interferons or interleukins
• More than 2 weeks since prior cytokine-fusion proteins
• More than 2 weeks since prior IV immunoglobulin (IVIG)
• No prior interleukin-12
• No concurrent cytokines
• No concurrent fenretinide
• No concurrent 13-cis-retinoic acid
• No other concurrent immunomodulators, including:
• * G-CSF and GM-CSF
• * Interferons
• * Other interleukins
• * IVIG
• More than 4 weeks since prior chemotherapy
• No other unstable medical condition or critical illness that would preclude study participation
• More than 12 weeks since prior myeloablative chemotherapy followed by autologous stem cell transplantation:
• No prior myeloablative chemotherapy followed by allogeneic bone marrow transplantation
• More than 2 weeks since prior growth hormones
• More than 4 weeks since prior systemic corticosteroids
• More than 2 weeks since prior non-corticosteroid hormonal therapy (including oral birth control pills)
• No concurrent hormonal therapy (including oral birth control pills)
• No concurrent growth hormones
• No concurrent systemic corticosteroids, except for use in life-threatening complications
• More than 4 weeks since prior radiotherapy
• No prior solid organ transplantation
• More than 4 weeks since prior investigational agents
• No other concurrent investigational agents
• No prior enrollment on COG-A3973, unless disease has progressed
• No history of hemolytic anemia
• Absolute neutrophil count at least 1,500/mm\^3 \[Note: Independent of growth factor or transfusion support\]
• Platelet count at least 75,000/mm\^3 \[Note: Independent of growth factor or transfusion support\]
• AST and ALT less than 2.5 times upper limit of normal
• Bilirubin less than 2.0 mg/dL
• Creatinine clearance or radioisotope glomerular filtration rate at least 70 mL/min OR creatinine normal
• HIV negative
• Ejection fraction at least 50% by echocardiogram or MUGA OR Fractional shortening at least 30% by echocardiogram
• No congestive heart failure
• No uncontrolled cardiac arrhythmia