Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Case Comprehensive Cancer Center
OBJECTIVES:
* Determine the effect of intraoperative radiotherapy boost to the tumor bed on acute complications after lumpectomy (before whole breast irradiation) in women with ductal carcinoma in situ or invasive adenocarcinoma of the breast.
* Determine the local recurrence rates in patients treated with this regimen.
* Determine the cosmetic outcome in patients treated with this regimen.
OUTLINE: Patients undergo excisional biopsy or surgery followed by an intraoperative dose of radiation to the tumor cavity. Postoperatively, patients undergo external beam radiotherapy to the entire breast 5 days a week for 5-6 weeks.
Patients are followed at 1 month and then every 3 months for 2 years.
PROJECTED ACCRUAL: A total of 25 patients will be accrued for this study within 2 years.
Age
18–120
Sex
FEMALE
Healthy volunteers
Not accepted
You may be eligible if
DISEASE CHARACTERISTICS:
Histologically confirmed ductal carcinoma in situ or invasive adenocarcinoma of the breast
* Primary tumor classified as T1, T2, or T3
Candidate for breast-conserving surgery
Must have undergone lumpectomy with negative margins or minimal margin involvement
Currently undergoing re-excision of the biopsy cavity and/or sentinel lymph node biopsy or axillary lymph node dissection
No evidence of metastatic disease
Hormone receptor status:
* Not specified
PATIENT CHARACTERISTICS:
Age
Adult
Sex
Female
Menopausal status
Not specified
Performance status
ECOG 0-2
Life expectancy
Not specified
Hematopoietic
WBC greater than 3,500/mm\^3
Granulocyte count greater than 1,500/mm\^3
Platelet count greater than 100,000/mm\^3
Hepatic
Not specified
Renal
Not specified
Other
Not pregnant
No other malignancies within the past 5 years except carcinoma in situ of the cervix or nonmelanoma skin cancer
* Prior contralateral breast cancer allowed if curatively treated more than 5 years previously
