3-AP in Treating Patients With Advanced Prostate Cancer

Inclusion Criteria

• •DISEASE CHARACTERISTICS:
• •Diagnosis of hormone-refractory metastatic prostate cancer by one of the following methods:
• •* Measurable disease
• •* PSA level of at least 5 ng/mL with a positive bone scan
• •Objective evidence of progressive metastatic disease in the past 3 months defined by any of the following:
• •* An increase in PSA value of at least 25% (minimum absolute increase of 5 ng/mL) on at least 2 successive occasions, at least 2 weeks apart
• •* A new symptomatic lesion on bone scan
• •* A new metastases not in bone
• •* Growth of existing non-bone measurable metastatic disease NOTE: An increase in pain or symptoms alone without other evidence of progression, or elevation of PSA or serum alkaline phosphatase alone without evidence of metastatic disease is not sufficient
• •Prior bilateral orchiectomy or other primary hormonal treatment with evidence of treatment failure
• +58 more criteria