Alicaforsen (ISIS 2302) in Patients With Active Crohn's Disease

Exclusion Criteria

• •1. Known severe, fixed, symptomatic stenosis of the small or large intestine with significant dilation
• •2. Extensive external fistulization (\> 3 external fistulae which are expressible with gentle compression); colostomy or ileostomy
• •3. Active infection, including infectious colitis, or infection with HIV, Hepatitis B or Hepatitis C
• •4. Malignancy within 3 years or poorly controlled medical illness
• •5. Requires intravenous heparin therapy or with a history of a bleeding problem