1. Known severe, fixed, symptomatic stenosis of the small or large intestine with significant dilation

2. Extensive external fistulization (\> 3 external fistulae which are expressible with gentle compression); colostomy or ileostomy

3. Active infection, including infectious colitis, or infection with HIV, Hepatitis B or Hepatitis C

4. Malignancy within 3 years or poorly controlled medical illness

5. Requires intravenous heparin therapy or with a history of a bleeding problem

Alicaforsen (ISIS 2302) in Patients With Active Crohn's Disease