Evaluate the Role of Adding Amaryl to Non-Insulin Dependent Diabetes Mellitus Patients Unresponsive to Maximum Dose Metformin & Thiazolidinedione

Exclusion Criteria

• •Patients who require insulin therapy or are currently on other sulfonylureas.
• •Patients with a history of hypersensitivity to sulfonylureas.
• •Patients with past history of severe hypoglycemia reaction on their current antidiabetic therapy requiring medical attention.
• •Patients with a history of acute metabolic complications such as hyperosmolar coma or ketonuria.
• •Patients with clinically significant abnormal baseline laboratory values (hematology, blood chemistry or urinalysis) which define a disease or condition, which in the opinion of the investigator may either put the patient at risk because of participation in the study, or may influence the results of the study, or the patient's ability to participate and complete the study. Should there be a laboratory value which, upon initial screening, is substantially outside the normal range, the test should be repeated.
• •Patients who had an increase in their thiazolidinedione medication within 2 months of entering the study (Visit 0).
• •Patients who had an increase in the metformin medication within 1 month of entering the study (Visit 0).
• •Patients whose body weight has changed more than 2% for patients \< 250 pounds or 3% for patients \>= 250 pounds, during the 4 week stabilization period when compared to the weight at the screening visit 0 (week - 4).
• •Patients with acute infections.
• •Patients who have received any drug (i.e. a chemotherapy agent) with a well-defined potential for toxicity to a major organ system during the three months prior to the study.
• •Patients with clinically significant renal or hepatic disease (i.e. ALT \> 2.5 x upper limit of normal) or gastrointestinal disorders that may interfere with absorption of the study drugs.
• •Patients who are allergic to sulfonamides and excipients.
• •Patients with any history of alcohol or drug abuse.
• •Pregnant or lactating females will be excluded.
• •Patients with a history of psychosis, emotional or intellectual problems that could impair the ability of the patient to participate in the study or to complete the study.
• •Patients who have participated in any investigational study within 30 days prior to Visit 0.