Pregnant or lactating female.

Conditions that would affect absorption of an oral drug

First-line regimen did not include 5-fluorouracil with irinotecan and/or oxaliplatin.

Serious medical or psychiatric disorder that would interfere with the patient''s safety or informed consent.

Severe cardiovascular disease or cardiac (heart) disease requiring a device.

Active infection.

Brain metastases.

Concurrent cancer therapy or investigational therapy.

Use of oral or intravenous steroids.

Unresolved or unstable, serious toxicity from prior therapy.

Prior therapy with an EGFR (Endothelial Growth Factor Receptor) and/or erbB-2 inhibitor.

GW572016, An Oral Drug For Colorectal Cancer Patients Having Prior Therapy With 5-FU Plus CPT-11 And/Or Oxaliplatin