Imatinib Mesylate in Treating Patients With Progressive, Refractory, or Recurrent Stage II or Stage III Testicular or Ovarian Cancer

Inclusion Criteria

• •Histologically confirmed pure testicular seminoma or ovarian germ cell dysgerminoma
• •* Histologic documentation of metastatic/recurrent disease not required
• •Alpha-fetoprotein level must be normal, unless abnormal level is explained by other conditions and approved by the study chair
• •Clinical stage II or III
• •Progressive, refractory, or recurrent disease, meeting at least 1 of the following criteria:
• •* Measurable progressive disease
• •* Biopsy-proven residual disease
• •* Persistently elevated or rising B-human chorionic gonadotropin (HCG) titers, defined as at least 2 values above the upper limit of normal (ULN)
• •Cisplatin-refractory disease without option of potentially curative therapy, meeting 1 of the following criteria:
• •* Failed high-dose chemotherapy with peripheral blood stem cell transplantation (PBSCT) or autologous bone marrow transplantation (AuBMT)
• •* Ineligible for or refused PBSCT or AuBMT
• •* Unlikely to achieve long-term benefit from PBSCT or AuBMT
• •Current evidence of metastatic disease
• •* Unidimensionally measurable target lesions
• •* At least 20 mm by conventional techniques (e.g., physical examination for clinically palpable lymph nodes and superficial skin lesions or chest x-ray for clearly defined lung lesions surrounded by aerated lung)
• •* At least 10 mm by spiral CT scan or MRI
• •* If measurable disease is confined to a solitary lesion, then its neoplastic nature must be confirmed by histology
• •* Ultrasound may not be used to measure tumor lesions that are not easily accessible clinically
• •Non-measurable/non-target lesions, with HCG at least ULN, including the following:
• •* Bone lesions
• •* Pleural or pericardial effusions
• •* Ascites
• •* CNS lesions
• •* Leptomeningeal disease
• •* Irradiated lesions, unless progression documented after radiotherapy
• •Performance status - ECOG 0-2
• •Granulocyte count at least 1,500/mm\^3
• •Platelet count at least 100,000/mm\^3
• •Hemoglobin at least 9 g/dL (transfusion allowed)
• •Bilirubin no greater than 1.5 times upper limit of normal (ULN)
• •SGOT/SGPT no greater than 2.5 times ULN
• •Creatinine no greater than 1.5 times ULN
• •No other severe and/or uncontrolled concurrent medical illness
• •Not pregnant or nursing
• •Negative pregnancy test
• •Fertile patients must use effective barrier contraception during and for 3 months after study participation
• •See Disease Characteristics
• •See Disease Characteristics
• •At least 4 weeks since prior chemotherapy
• •No concurrent chemotherapy
• •No concurrent hormonal therapy except steroids for adrenal failure, hormones for non-disease-related conditions (e.g., insulin for diabetes), or intermittent dexamethasone as an antiemetic
• •See Disease Characteristics
• •At least 4 weeks since prior radiotherapy
• •Prior radiotherapy to a symptomatic lesion or one that may produce disability (e.g., unstable femur) allowed
• •No concurrent palliative radiotherapy
• •No concurrent grapefruit juice
• •No concurrent warfarin for therapeutic anticoagulation (concurrent mini-dose warfarin \[1 mg orally per day\] as prophylaxis allowed)