Comparison of Biomarkers Based on Fine-Needle Aspiration in Women at Increased or Normal Risk of Breast Cancer

Inclusion Criteria

• •DISEASE CHARACTERISTICS:
• •Increased risk of breast cancer as determined by 1 or more first-degree relatives (mother, sister, or daughter) with a history of breast cancer OR a personal history of atypical hyperplasia, lobular carcinoma in situ, or ductal carcinoma in situ of the breast OR
• •No increased risk of breast cancer as determined by a lack of the above conditions
• •Scheduled to undergo elective breast surgery for removal of a mammographic lesion or palpable breast lump
• •No prior bilateral mastectomy or bilateral breast irradiation
• •Hormone receptor status:
• •* Not specified
• •PATIENT CHARACTERISTICS:
• •Age:
• •30 and over
• •Sex:
• •Female
• •Menopausal status:
• •Not specified
• •Performance status:
• •Not specified
• •Life expectancy:
• •Not specified
• •Hematopoietic:
• •Not specified
• •Hepatic:
• •Not specified
• •Renal:
• •Not specified
• •Other:
• •No active invasive malignancy in any site except basal cell or squamous cell skin cancer
• •No significant medical or psychiatric problems that would preclude study
• •No evidence of excessive use of narcotics or drug dependency
• •PRIOR CONCURRENT THERAPY:
• •Biologic therapy:
• •Not specified
• •Chemotherapy:
• •Not specified
• •Endocrine therapy:
• •Not specified
• •Radiotherapy:
• •See Disease Characteristics
• •Surgery:
• •See Disease Characteristics