BAY 59-8862 in Treating Patients With Refractory Non-Hodgkin's Lymphoma

You may be eligible if

• DISEASE CHARACTERISTICS:
• Histologically confirmed aggressive refractory non-Hodgkin's lymphoma (NHL) of one of the following classifications, and for which chemotherapy is deemed appropriate:
• * Diffuse large B-cell lymphoma
• * Transformed NHL
• * Follicular large cell lymphoma
• * Peripheral T cell lymphoma
• * Anaplastic large cell lymphoma
• * Mantle cell lymphoma
• * Unclassified aggressive histology
• * Immunoblastic lymphoma
• Failed at least 1 prior therapy (primary resistant) OR
• Previously achieved a remission and then progressed or relapsed within 6 months of therapy
• At least 1 bidimensionally measurable lesion
• * Lesions within a previously irradiated field are not considered measurable
• No relapse within 6 months after prior autologous bone marrow transplantation
• No prior allogeneic bone marrow or stem cell transplantation or post-transplant lymphoproliferative disorder
• No parenchymal or meningeal CNS involvement unless the patient received prior definitive therapy more than 6 months ago, has had a negative imaging study within the past 4 weeks, and is clinically stable with respect to the tumor at study entry
• PATIENT CHARACTERISTICS:
• Age:
• 18 and over
• Performance status:
• ECOG 0-2
• Life expectancy:
• At least 12 weeks
• Hematopoietic:
• Absolute neutrophil count at least 1,500/mm\^3
• Platelet count at least 75,000/mm\^3
• Hemoglobin at least 9.0 g/dL
• Hepatic:
• Total bilirubin no greater than 1.5 times upper limit of normal (ULN)
• ALT and AST no greater than 2.0 times ULN (5.0 times ULN if hepatic involvement)
• PT, INR, and PTT less than 1.5 times ULN
• No chronic hepatitis B or C
• Renal:
• Creatinine no greater than 1.5 times ULN
• Cardiovascular:
• No clinically evident congestive heart failure
• No New York Heart Association class III or IV heart disease
• No serious cardiac arrhythmias
• No active coronary artery disease or ischemia
• Other:
• No prior hypersensitivity to taxane compounds
• No known or suspected allergy to the investigational study agent or any agent given in association with this study
• No other prior or concurrent malignancy except basal cell skin cancer or curatively treated carcinoma in situ of the bladder or cervix (adequately cone biopsied)
• No substance abuse or medical, psychological, or social conditions that would preclude study participation
• No active clinically serious infections
• No other condition that is unstable or would preclude study participation
• No grade 2 or greater pre-existing peripheral neuropathy
• No history of seizure disorder
• * Prior seizures related to brain metastases allowed provided that the patient has been seizure-free for at least 2 months
• HIV negative
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective barrier contraception
• PRIOR CONCURRENT THERAPY:
• Biologic therapy:
• See Disease Characteristics
• See Chemotherapy
• At least 4 weeks since prior anticancer immunotherapy
• At least 3 weeks since prior biologic response modifiers (e.g., filgrastim \[G-CSF\])
• No concurrent anticancer immunotherapy
• No concurrent prophylactic G-CSF
• Concurrent G-CSF or other hematopoietic growth factors for acute toxicity (e.g., febrile neutropenia) allowed
• Concurrent chronic epoetin alfa allowed provided no dose adjustment occurred within 2 months prior to study
• Chemotherapy:
• See Disease Characteristics
• At least 4 weeks since prior anticancer chemotherapy
• No more than 3 prior systemic chemotherapy regimens for metastatic NHL:
• * High-dose therapy for autologous hematopoietic stem cell transplantation (SCT) is considered 1 prior regimen
• * Salvage chemotherapy followed by autologous bone marrow transplant or peripheral SCT is considered 1 prior regimen
• * Antibody treatment is not considered 1 prior regimen
• No prior taxanes or oxaliplatin
• No other concurrent anticancer chemotherapy
• Endocrine therapy:
• Patients with prior parenchymal or meningeal CNS involvement:
• * No concurrent acute or tapered steroid therapy
• * Concurrent chronic steroid therapy allowed provided the dose is stable for 1 month before and after screening radiographic studies
• Radiotherapy:
• See Disease Characteristics
• At least 4 weeks since prior radiotherapy
• Concurrent palliative radiotherapy allowed provided:
• * No progressive disease
• * No more than 10% of bone marrow is irradiated
• * Radiation field does not encompass a target lesion
• No other concurrent radiotherapy
• Surgery:
• At least 4 weeks since prior major surgery
• Other:
• At least 4 weeks since prior investigational drugs
• No other concurrent investigational therapy or approved anticancer therapy
• No concurrent illicit drugs or other substances that would preclude study
• Concurrent therapeutic anticoagulants (e.g., warfarin or heparin) allowed provided there is no prior evidence of underlying abnormality with PT, INR, or PTT
• Concurrent nonconventional therapies (e.g., herbs or acupuncture) or vitamin/mineral supplements allowed provided that they do not interfere with study endpoints
• Concurrent bisphosphonates for prophylaxis or bone metastases allowed