UCN-01 and Carboplatin in Treating Patients With Advanced Solid Tumors

PRIMARY OBJECTIVES: I. Determine the maximum tolerated dose, dose limiting toxicity and other toxicities of UCN-01 when combined with carboplatin. II. Preliminarily evaluate the antitumor effect of the combination of carboplatin and UCN-01. III. Determine the pharmacokinetics of UCN-01 and carboplatin. OUTLINE: This is a dose-escalation study. Patients receive carboplatin IV over 1 hour followed by UCN-01 IV over 3 hours on day 1. Treatment repeats every 21 days for up to 6 courses in the absence of disease progression or unacceptable toxicity. Cohorts of 3-6 patients receive escalating doses of carboplatin and UCN-01 until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity.