Use of dopamine agonist medications and other medications in defined timeframe

Unstable dose of CNS active therapies (eg, hypnotics, antidepressants, anxiolytics) within the last 30 days

Atypical Parkinson's syndromes due to drugs, metabolic disorders, encephalitis, or degenerative diseases

Dementia

History of active epilepsy within the past year

Significant liver disease with defined laboratory criteria

Significant renal disease with defined laboratory criteria

Certain cardiac conditions

Electroconvulsive therapy in the previous 90 days

Subjects participating in other drug studies or receiving other investigational drugs within previous 30 days

Positive pregnancy test at Screen

Unwillingness to use adequate contraceptive methods

Lactating women

History of stereotaxic brain surgery

Malignant melanoma or history of treated melanoma

Open Label Sumanirole Study of Safety, Tolerability, and Therapeutic Response In Patients With Parkinson's Disease