Radiation Therapy in Treating Patients With Aggressive Fibromatoses

Inclusion Criteria

• •DISEASE CHARACTERISTICS:
• •Histologically confirmed aggressive fibromatoses arising in any site
• •* Primary, recurrent, or progressive disease that is inoperable or requires a major operation resulting in a large functional or cosmetic deficit or mutilation
• •* Progressive disease defined as at least 20% increase in tumor size on 2 MRI scans within 1 year after any prior therapy except radiotherapy OR
• •* Incompletely resected tumor with gross residual disease not suitable for further surgery
• •* Resected within the past 3 months
• •Lesions must be suitable for radiotherapy
• •* No bulky intra-abdominal disease in close relation to small bowel
• •Measurable disease
• •PATIENT CHARACTERISTICS:
• •Age:
• •16 and over
• •Performance status:
• •Not specified
• •Life expectancy:
• •Not specified
• •Hematopoietic:
• •Not specified
• •Hepatic:
• •Not specified
• •Renal:
• •Not specified
• •Other:
• •No conditions that would preclude study follow-up
• •PRIOR CONCURRENT THERAPY:
• •Biologic therapy:
• •Not specified
• •Chemotherapy:
• •Prior chemotherapy allowed
• •No concurrent chemotherapy
• •Endocrine therapy:
• •Prior endocrine therapy allowed
• •No concurrent endocrine therapy
• •Radiotherapy:
• •See Disease Characteristics
• •No prior radiotherapy to indicator lesion
• •Surgery:
• •See Disease Characteristics
• •Prior surgery allowed
• •Other:
• •No prior isolated limb perfusion with tumor necrosis factor
• •No concurrent isolated limb perfusion with tumor necrosis factor