Signed informed consent

Greater than 18 years of age

Proof of breast cancer, multiple myeloma or prostate cancer

Diagnosis of at least one cancer-related bone lesion

If patient is of child-bearing potential, negative pregnancy test and on a medically recognized form of contraception

ECOG performance status of 0,1 or 2

Ability to read, understand and write English or Spanish language

Normal renal function

Treatment With Zoledronic Acid in Patients With Breast Cancer, Multiple Myeloma, and Prostate Cancer With Cancer Related Bone Lesions